Home

USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database 
Search by   *
 
 
 
 
 
 
Maps   
 
 

     Select Remote Interfaces
[All Interfaces]
SWISS-2DPAGE
World-2DPAGE Portal
World-2DPAGE Repository
Exclude local DBs
has only effect if a remote
interface is selected
     
Searching in 'USC-OGP 2-DE database' for entry matching: ACTB_HUMAN




USC-OGP 2-DE database:  ACTB_HUMAN

ACTB_HUMAN


General information about the entry
View entry in simple text format
Entry nameACTB_HUMAN
Primary accession numberP60709
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Actin, cytoplasmic 1; AltName: Full=Beta-actin; Contains: RecName: Full=Actin, cytoplasmic 1, N-terminally processed;.
Gene nameName=ACTB
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-5 {PLATELET 4-5}
Homo sapiens (Human)
PLATELET_4-5
  map experimental info 		 
PLATELET_4-5

MAP LOCATIONS:
pI=4.63; Mw=52202
pI=4.45; Mw=50169
pI=4.72; Mw=45607
pI=5.04; Mw=40309
pI=4.86; Mw=38026
pI=4.73; Mw=34534
pI=4.91; Mw=33585
pI=5.03; Mw=31988
pI=4.87; Mw=31876
pI=5.02; Mw=30562
pI=4.92; Mw=30031
pI=4.92; Mw=16575
pI=4.96; Mw=16353



PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info 		 
PLATELET_4-7

MAP LOCATIONS:
pI=5.21; Mw=120018
pI=5.13; Mw=107696
pI=5.12; Mw=95000
pI=5.12; Mw=84870
pI=5.18; Mw=48891
pI=5.10; Mw=48653
pI=5.14; Mw=48298
pI=5.45; Mw=44776
pI=5.41; Mw=44667
pI=5.34; Mw=44558
pI=5.64; Mw=44558
pI=5.41; Mw=42956
pI=5.53; Mw=42956
pI=5.53; Mw=42022
pI=5.13; Mw=31502
pI=5.13; Mw=29469
pI=5.26; Mw=27760
pI=5.11; Mw=26520
pI=5.28; Mw=25695



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info 		 
PLATELET_5-6

MAP LOCATIONS:
pI=5.13; Mw=102264
pI=5.15; Mw=93758
pI=5.11; Mw=50050
pI=5.14; Mw=49554
pI=5.41; Mw=45994
pI=5.32; Mw=44865
pI=5.47; Mw=44865
pI=5.29; Mw=44531
pI=5.56; Mw=42795
pI=5.55; Mw=42162
pI=5.13; Mw=31522
pI=5.23; Mw=29794
pI=5.10; Mw=29413
pI=5.24; Mw=28514
pI=5.25; Mw=28162



PLATELET_6-11 {PLATELET 6-11}
Homo sapiens (Human)
PLATELET_6-11
  map experimental info 		 
PLATELET_6-11

MAP LOCATIONS:
pI=6.02; Mw=45707
pI=6.89; Mw=45068
pI=8.15; Mw=44333
pI=7.22; Mw=44126
pI=5.53; Mw=43508
pI=5.85; Mw=42599
pI=10.08; Mw=42499



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info 		 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=5.44; Mw=49904
pI=6.39; Mw=46315
pI=5.91; Mw=45157
pI=6.62; Mw=45030
pI=5.57; Mw=44777
pI=5.29; Mw=44651
pI=5.40; Mw=44276
pI=5.12; Mw=42209
pI=5.96; Mw=39564
pI=6.30; Mw=36464
pI=6.05; Mw=32675
pI=5.01; Mw=31502
pI=5.39; Mw=30456
pI=5.08; Mw=30030
pI=5.04; Mw=29946

Cross-references
UniProtKB/Swiss-ProtP60709; ACTB_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameACTB_HUMAN
Primary accession numberP60709
Secondary accession number(s) P02570 P70514 P99021 Q11211 Q64316 Q75MN2 Q96B34 Q96HG5
Sequence was last modified on April 1, 1988 (version 1)
Annotations were last modified on March 15, 2017 (version 161)
Name and origin of the protein
DescriptionRecName: Full=Actin, cytoplasmic 1; AltName: Full=Beta-actin; Contains: RecName: Full=Actin, cytoplasmic 1, N-terminally processed;
Gene nameName=ACTB
Encoded onName=ACTB
Keywords3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Deafness; Direct protein sequencing; Disease mutation; Dystonia; Isopeptide bond; Mental retardation; Methylation; Nucleotide-binding; Oxidation; Polymorphism; Reference proteome; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX00351; CAA25099.1; -; mRNA
EMBLM10277; AAA51567.1; -; Genomic_DNA
EMBLX63432; CAA45026.1; -; mRNA
EMBLAY582799; AAS79319.1; -; Genomic_DNA
EMBLAC006483; AAP22343.1; -; Genomic_DNA
EMBLBC001301; AAH01301.1; -; mRNA
EMBLBC002409; AAH02409.1; -; mRNA
EMBLBC004251; AAH04251.1; -; mRNA
EMBLBC008633; AAH08633.1; -; mRNA
EMBLBC012854; AAH12854.1; -; mRNA
EMBLBC013380; AAH13380.1; -; mRNA
EMBLBC014861; AAH14861.1; -; mRNA
EMBLBC016045; AAH16045.1; -; mRNA
EMBLV00478; CAA23745.1; -; mRNA
CCDSCCDS5341.1; -; .
PIRA25168; ATHUB; .
RefSeqNP_001092.1; NM_001101.3; .
UniGeneHs.520640; -; .
PDB3BYH; EM; 12.00 A; A=2-375
PDB3D2U; X-ray; 2.21 A; C/G=170-178
PDB3J82; EM; 7.70 A; B/C/D=2-375
PDB3LUE; EM; -; A/B/C/D/E/F/G/H/I/J=2-375
PDBsum3BYH; -; .
PDBsum3D2U; -; .
PDBsum3J82; -; .
PDBsum3LUE; -; .
ProteinModelPortalP60709; -; .
SMRP60709; -; .
BioGrid106575; 281; .
DIPDIP-29686N; -; .
IntActP60709; 197; .
MINTMINT-220312; -; .
STRING9606.ENSP00000349960; -; .
ChEMBLCHEMBL2062353; -; .
iPTMnetP60709; -; .
PhosphoSitePlusP60709; -; .
SwissPalmP60709; -; .
BioMutaACTB; -; .
DMDM46397333; -; .
DOSAC-COBS-2DPAGEP60709; -; .
REPRODUCTION-2DPAGEP60709; -; .
SWISS-2DPAGEP60709; -; .
UCD-2DPAGEP60709; -; .
EPDP60709; -; .
PaxDbP60709; -; .
PeptideAtlasP60709; -; .
PRIDEP60709; -; .
TopDownProteomicsP60709; -; .
DNASU60; -; .
EnsemblENST00000331789; ENSP00000349960; ENSG00000075624; .
GeneID60; -; .
KEGGhsa:60; -; .
CTD60; -; .
DisGeNET60; -; .
GeneCardsACTB; -; .
HGNCHGNC:132; ACTB; .
HPACAB002621; -; .
HPAHPA041264; -; .
HPAHPA041271; -; .
MalaCardsACTB; -; .
MIM102630; gene; .
MIM243310; phenotype; .
MIM607371; phenotype; .
neXtProtNX_P60709; -; .
OpenTargetsENSG00000075624; -; .
Orphanet2995; Baraitser-Winter syndrome; .
Orphanet79107; Developmental malformations - deafness - dystonia; .
PharmGKBPA24457; -; .
eggNOGKOG0676; Eukaryota; .
eggNOGCOG5277; LUCA; .
GeneTreeENSGT00760000118957; -; .
HOVERGENHBG003771; -; .
InParanoidP60709; -; .
KOK05692; -; .
OMAPFHTTAE; -; .
OrthoDBEOG091G08LD; -; .
PhylomeDBP60709; -; .
TreeFamTF354237; -; .
ReactomeR-HSA-1445148; Translocation of GLUT4 to the plasma membrane; .
ReactomeR-HSA-190873; Gap junction degradation; .
ReactomeR-HSA-196025; Formation of annular gap junctions; .
ReactomeR-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation; .
ReactomeR-HSA-3214847; HATs acetylate histones; .
ReactomeR-HSA-389957; Prefoldin mediated transfer of substrate to CCT/TriC; .
ReactomeR-HSA-390450; Folding of actin by CCT/TriC; .
ReactomeR-HSA-3928662; EPHB-mediated forward signaling; .
ReactomeR-HSA-3928665; EPH-ephrin mediated repulsion of cells; .
ReactomeR-HSA-418990; Adherens junctions interactions; .
ReactomeR-HSA-437239; Recycling pathway of L1; .
ReactomeR-HSA-4420097; VEGFA-VEGFR2 Pathway; .
ReactomeR-HSA-445095; Interaction between L1 and Ankyrins; .
ReactomeR-HSA-446353; Cell-extracellular matrix interactions; .
ReactomeR-HSA-5250924; B-WICH complex positively regulates rRNA expression; .
ReactomeR-HSA-5626467; RHO GTPases activate IQGAPs; .
ReactomeR-HSA-5663213; RHO GTPases Activate WASPs and WAVEs; .
ReactomeR-HSA-5663220; RHO GTPases Activate Formins; .
ReactomeR-HSA-5674135; MAP2K and MAPK activation; .
ReactomeR-HSA-5689603; UCH proteinases; .
ReactomeR-HSA-5696394; DNA Damage Recognition in GG-NER; .
ReactomeR-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; .
ReactomeR-HSA-6802948; Signaling by high-kinase activity BRAF mutants; .
ReactomeR-HSA-6802949; Signaling by RAS mutants; .
ReactomeR-HSA-6802952; Signaling by BRAF and RAF fusions; .
ReactomeR-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; .
ReactomeR-HSA-8856828; Clathrin-mediated endocytosis; .
ReactomeR-HSA-983231; Factors involved in megakaryocyte development and platelet production; .
SignaLinkP60709; -; .
ChiTaRSACTB; human; .
EvolutionaryTraceP60709; -; .
GeneWikiBeta-actin; -; .
GenomeRNAi60; -; .
PROPR:P60709; -; .
ProteomesUP000005640; Chromosome 7; .
BgeeENSG00000075624; -; .
CleanExHS_ACTB; -; .
ExpressionAtlasP60709; baseline and differential; .
GenevisibleP60709; HS; .
GOGO:0072562; C:blood microparticle; IDA:UniProtKB; .
GOGO:0030863; C:cortical cytoskeleton; IEA:Ensembl; .
GOGO:0005737; C:cytoplasm; TAS:UniProtKB; .
GOGO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL; .
GOGO:0005856; C:cytoskeleton; TAS:UniProtKB; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0097433; C:dense body; ISS:AgBase; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0005615; C:extracellular space; IDA:UniProtKB; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0043209; C:myelin sheath; IEA:Ensembl; .
GOGO:0035267; C:NuA4 histone acetyltransferase complex; IDA:UniProtKB; .
GOGO:0000790; C:nuclear chromatin; IDA:UniProtKB; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0005886; C:plasma membrane; ISS:AgBase; .
GOGO:0043234; C:protein complex; IDA:UniProtKB; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0042802; F:identical protein binding; IPI:IntAct; .
GOGO:0019894; F:kinesin binding; IPI:UniProtKB; .
GOGO:0050998; F:nitric-oxide synthase binding; IPI:BHF-UCL; .
GOGO:0005200; F:structural constituent of cytoskeleton; TAS:UniProtKB; .
GOGO:0098973; F:structural constituent of postsynaptic actin cytoskeleton; IDA:SynGO; .
GOGO:0030957; F:Tat protein binding; IPI:BHF-UCL; .
GOGO:0043044; P:ATP-dependent chromatin remodeling; IDA:UniProtKB; .
GOGO:0034329; P:cell junction assembly; TAS:Reactome; .
GOGO:0048013; P:ephrin receptor signaling pathway; TAS:Reactome; .
GOGO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome; .
GOGO:0061024; P:membrane organization; TAS:Reactome; .
GOGO:0006928; P:movement of cell or subcellular component; TAS:UniProtKB; .
GOGO:0070527; P:platelet aggregation; IMP:UniProtKB; .
GOGO:0045815; P:positive regulation of gene expression; epigenetic; TAS:Reactome
GOGO:0098974; P:postsynaptic actin cytoskeleton organization; IDA:SynGO; .
GOGO:0016579; P:protein deubiquitination; TAS:Reactome; .
GOGO:0001895; P:retina homeostasis; IEP:UniProtKB; .
GOGO:0021762; P:substantia nigra development; IEP:UniProtKB; .
GOGO:0048010; P:vascular endothelial growth factor receptor signaling pathway; TAS:Reactome; .
InterProIPR004000; Actin; .
InterProIPR020902; Actin/actin-like_CS; .
InterProIPR004001; Actin_CS; .
PANTHERPTHR11937; PTHR11937; 1; .
PfamPF00022; Actin; 1; .
PRINTSPR00190; ACTIN; .
SMARTSM00268; ACTIN; 1; .
PROSITEPS00406; ACTINS_1; 1; .
PROSITEPS00432; ACTINS_2; 1; .
PROSITEPS01132; ACTINS_ACT_LIKE; 1; .


USC-OGP 2-DE database image

Gateways to other related servers

Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

[Home]